Charles is related to the Campbell family of Auchenbreck, Scotland. His (5) Great-Grandfather, John Campbell was "severely wounded at the Battle of Inverlochy in 1645," his "younger son (William Campbell,)(4) was born in Campbelltown, Scotland, about 1660. He died in Londonderry, Ireland, in 1723. He was engaged in the Monmouth Rebellion and escaped to Londonderry about 1685. He was a Lieutenant Colonel in the Siege of Londonderry, and was spoken of by a poet, as 'brave Campbell.'"
William's eldest son John (3) was born about 1688, John and his son James (2)(b.1720) likely moved to the scotch-irish colony in Ulster, Ireland along with many Scotish migrants during the Reformation in England. In a move against England's religious impositions "1/3 of the population of Ulster, 200,000 people emmigrated to America during the colonial period." Among them John and his seven children. James who arrived separate from his father brought his son Samuel (1,) born in Ireland around 1743. Samuel married Martha Cooper 1767. They were members of the Monmouth Presbyterian Church of Rockbridge County, Virginia. They moved to Shelby County, Kentucky, where he bought one thousand acres of land on Bullskin River. He died in 1804 and is buried at Olivet Church Cemetery, near Chester Grove, Shelby Co. Kentucky. Samuel fought in the American Revolution, the Rockbridge Co, Virginia, Order Book No. 1, Page 56 reads, "On the Eight Day of December, 1778, Samuel McCampbell produced a commission from his Excellency, The Governor, appointing him Ensign in a company of Militia in the County, who took the oath required by law." His son Andrew, (Charles' grandfather,) is listed in his father's will, "To Son Andrew, the plantation, my present place of residence, containing 200 acres, after the death of his mother." Andrew married Hannah Holmes and had 8 children. Their first son Samuel A. McCampbell was born January 31, 1812, he married Martha Elliot, they lived in Parke County, Indiana. He died in Marshall, Indiana. Samuel A. and Martha had 7 children their youngest child was Charles F. McCampbell, born July 6, 1857. He married Esta Cook February 9, 1880.